Exploring biomarkers and therapeutic targets by genome copy number variation
نویسندگان
چکیده
منابع مشابه
copy number variation detection in sheep genome by using ovine beadchip 50k
introduction recently, genomic research in livestock is focused on genomic variation and its effect on phenotypic performance in economic traits. copy number variation (cnv) is one of these variations in genome including insertion, deletion and duplication of 1 kb to 1 mb segment with more than 90% similarity. cnvs can change gene structure and dosage, can regulate gene expression and function ...
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DNA copy number variation (CNV) was recently discovered as a significant part of human genetic variation. This variation affects genes as well as intergenic regions. Herein, current insight into the effects of CNV on gene expression is summarized. The consequences of intergenic CNVs are poorly understood. For CNV affecting genes, a dosage compensation mechanism seems to be applied on a subset o...
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Besides single-nucleotide variants in the human genome, large-scale genomic variants, such as copy number variations (CNVs), are being increasingly discovered as a genetic source of human diversity and the pathogenic factors of diseases. Recent experimental findings have shed light on the links between different genome architectures and CNV mutagenesis. In this review, we summarize various geno...
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Background: Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) gene is an inhibitor of apoptosis that expresses in human embryonic tissues but it is absent in most healthy adult tissues. The copy number of BIRC5 has been indicated to be highly increased in tumor tissues; however, its association with the age of onset in breast cancer is not well understood. Methods: Forty tumor tiss...
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ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2019
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.92.0_2-s15-3